Signal Transduction Reagents and Kits
Selleck Chemical LLC SB202190 (FHPI) 100mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam ZIP, protein kinase Czeta (PKC-zeta) inhibitor
Novel, cell-permeable protein kinase Cζ (PKCζ) inhibitor
The product is subject to the following: Abcam Restricted Use Statement
Cell Biolabs Inc ViraDuctin™ Lentivirus Transduction Kit, 40 transductions
The rate at which lentiviral vectors bind to and infect cells is mostly controlled by diffusion. During lentivirus infection, only a small fraction of the lentiviral vectors can transduce target cells. Virion adsorption is the limiting step of this process. The use of polycations, such as Polybrene, is standard in many lentiviral infection protocols owing to the observations of improved infection efficiency. Its mechanism of action is thought to involve neutralization of electrostatic repulsion between virion and cell membranes, enhancing attachment. ViraDuctin™ Lentivirus Transduction Kit is a proprietary formulation for the transduction of lentivirus. After forming a complex with lentivirus in culture medium, the ViraDuctin™ reagents typically provide higher transduction efficiency in many cell types compared to reagents such as Polybrene. It is ideal for transduction of nonpermissive cells such as primary cells and stem cells. 40 transductions.
Enzo Life Sciences SAG, (1mg), CAS Number: 364590-63-6
Smoothened ligand. A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine (BML-GR334) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Formula: C28H28ClN3OS. MW: 490.1. CAS Number: 364590-63-6. Purity: ≥95% (HR-MS, 1H-NMR, 13C-NMR). Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility). Use/Stability: Stable for at least 6 months when stored at -20°C. Long Term Storage: -20°C
BPS Bioscience Inc NFAT EGFP REPORTER LENTIVIRUS
The NFAT eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. BPS BIOSCIENCE INC mfg# 79922
AdipoGen SB202190 (1 mg)
SB202190 (1 mg), Adipogen Life Sciences. Chemical. CAS: 152121-30-7. Formula: C20H14FN3O. MW: 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer
Sigma Aldrich Fine Chemicals Biosciences PGO Enzyme Preparation 1 G capsules | 10CAP
PGO Enzyme Preparation 1 G capsules | 10CAP
Apexbio Technology LLC Zolmitriptan 139264-17-8 100mg
Zolmitriptan (CAS 139264-17-8) is a synthetic small molecule that functions as a selective agonist of serotonin 5-HT1B and 5-HT1D receptors By stimulating these receptors zolmitriptan modulates trigeminovascular neurotransmission leading to cranial vasoconstriction and inhibition of pro-inflammatory neuropeptide release These mechanisms underlie its ability to acutely alleviate migraine attacks both with and without aura as well as cluster headaches In biomedical research zolmitriptan serves as a tool compound for investigating serotonergic signaling pathways involved in nociception and vascular regulation associated with headache disorders
Aat Bioquest Calbryte 520 AM (10x50 ug)
The intracellular calcium flux assay is a widely used method in monitoring signal transduction pathways and high throughput screening of G proteinquotcoupled receptors GPCRs and calcium channel targets. This catalog is for 10x50 ug.
BPS Bioscience Inc SBE Reporter HEK293 Cell Line, 2 vials of frozen cells, 2 x 10^6 cells in 1 ml of cell freezing medium, ~1.5 x 10^6 cells in 1 ml of 10% DMSO, >1 x 10^6 cells in 1 ml of freezing medium, adherent growth properties
SBE Reporter HEK293 Cell Line, 2 vials of frozen cells, 2 x 10^6 cells in 1 ml of cell freezing medium, ~1.5 x 10^6 cells in 1 ml of 10% DMSO, >1 x 10^6 cells in 1 ml of freezing medium, adherent growth properties